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Publications – Doering Lab
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Publications

Lucy X. Li, Angel Ashikov, Hong Liu, Cara L. Griffith, Hans Bakker, and Tamara L. Doering. Cryptococcus neoformans UGT1 encodes a UDP-Galactose/UDP-GalNAc transporter. Glycobiology, 27, 87-98, 2017. [27496760] PMCID: PMC5193108

Felipe H. Santiago-Tirado, Michael D. Onken, John A. Cooper, Robyn S. Klein, and Tamara L. Doering. Trojan horse transit contributes to blood-brain barrier crossing of a eukaryotic pathogen. mBio, 8. doi: 10.1128/mBio.02183-16, 2017. [28143979] Media attention (click here)

Ezekiel J. Maier, Brian C. Haynes, Stacey R. Gish, Zhuo A. Wang, Michael L. Skowyra, Alyssa L. Marulli, Tamara L. Doering, and Michael R. Brent. Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation. Genome Research, 25, 690-700, 2015. [25644834]

Felipe H. Santiago-Tirado, Tao Peng, Meng Yang, Howard C. Hang, and Tamara L. Doering. A single protein S-acyltransferase is a major determinant of cryptococcal pathogenesis. PLoS Pathogens, 11(5):e1004908. doi: 10.1371/journal.ppat.1004908, 2015. [25970403]

Stacey R. Gish, Ezekiel J. Maier, Brian C. Haynes, Felipe H. Santiago, Deepa L. Srikanta, Matt Williams, Erika C. Crouch, Shabaana Khader, Michael R. Brent, and Tamara L. Doering. Usv101 is a key regulator of cryptococcal virulence and determinant of host response. mBio, 7, 313-316. doi: 10.1128/mBio.00313-16, 2016 [27094327]

REVIEW ARTICLE: Felipe H. Santiago-Tirado and Tamara L. Doering. All about that fat: Lipid modification of proteins in Cryptococcus neoformans. Journal of Microbiology 54, 212-222, 2016. [26920881]

Christian Heiss, Michael L. Skowyra, Hong Liu, J. Stacey Klutts, Zhirui Wang, Matthew Williams, Deepa Srikanta, Stephen M. Beverley, Parastoo Azadi, and Tamara L. Doering. Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans. J. Biol. Chem., 288, 10994-11003, 2013.

Therese Wohlschlager, Reto Buser, Michael L. Skowyra, Brian C. Haynes, Bernard Henrissat, Tamara L. Doering, Markus Künzler, and Markus Aebi. Identification of the galactosyl transferase of Cryptococcus neoformans involved in the biosynthesis of basidiomycete-type glycosylinositol-phosphoceramide. Glycobiology, 11, 1210-1219, 2013.

REVIEW ARTICLE: Deepa Srikanta, Felipe H. Santiago-Tirado, and Tamara L. Doering. Cryptococcus neoformans: Historical curiosity to modern pathogen. Yeast, 31, 47-60, 2014. [24375706]

Pardeep Kumar, Christian Heiss, Felipe H. Santiago-Tirado, Ian Black, Parastoo Azadi, and Tamara L. Doering. Pbx proteins in Cryptococcus neoformans cell wall remodeling and capsule assembly. Eukaryotic Cell, 13, 560-71, 2014 [24585882].

Zhuo A. Wang, Cara L. Griffith, Michael L. Skowyra, Nicole Salinas, Matthew Williams, Ezekiel J. Maier, Stacey R. Gish, Hong Liu, Michael R. Brent, and Tamara L. Doering. The dual GDP-mannose transporters of Cryptococcus neoformans and their role in biology and virulence. Eukaryotic Cell, 13, 832-42, 2014. [24747214]

Sanjoy Paul, Tamara L. Doering, and W. Scott Moye-Rowley. Cryptococcus neoformans Yap1 is required for normal fluconazole and stress resistance. Fungal Genetics and Biology, 74C:1-9, 2014. [25445311]

REVIEW ARTICLE: Deepa Srikanta, Felipe H. Santiago-Tirado, and Tamara L. Doering. Cryptococcus neoformans: Historical curiosity to modern pathogen. Yeast, 31, 47-60, 2014. [24375706]

REVIEW ARTICLE: Kyung J. Kwon-Chung, James A. Fraser, Tamara L. Doering, Zhuo A. Wang, Guilhem Janbon, Alexander Idnurm, and Yong-Sun Bahn. Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis. Cold Spring Harbor Perspectives in Medicine, 2014. 4:a019760. doi: 10.1101/cshperspect.a019760. [24985132]

Brian C. Haynes, Michael L. Skowyra, Sarah J. Spencer, Stacey R. Gish, Matthew Williams, Elizabeth P. Held, Michael R. Brent, and Tamara L. Doering. Toward an integrated model of capsule regulation in Cryptococcus neoformans. PLoS Pathogens 7(12): e1002411. doi:10.1371/journal.ppat.1002311, 2011. [PDF]

Pardeep Kumar, Meng Yang, Brian C. Haynes, Michael L. Skowyra, and Tamara L. Doering. Emerging themes in cryptococcal capsule synthesis. Current Opinion in Structural Biology 21:597-602, 2011. [PDF]

Deepa Srikanta, Meng Yang, Matthew Williams, and Tamara L. Doering. A sensitive high-throughput assay for evaulating host-pathogen interactions in Cryptococcus neoformans infection. PLoS ONE 6(7):e22773. doi:10:1371/journal.pone.0022773, 2011. [PDF]

Morgann C. Reilly, Kazuhiro Aoki, Zhou A. Wang, Michael L. Skowyra, Matthew Williams, Michael Tiemeyer, and Tamara L. Doering. A xylosylphosphotransferase of Cryptococcus neoformansacts in protein O-glycan synthesis. J. Biol. Chem. 286:26888-99, 2011. [PDF]

Indrani Bose and Tamara L. Doering. Efficient implementation of RNA interference in the pathogenic yeast Cryptococcus neoformans. Journal of Microbiological Methods, 86:156-9, 2011.

REVIEW ARTICLE: Guilhem Janbon and Tamara L. Doering. Biosynthesis and genetics of the Cryptococcal capsule. In: Cryptococcus: From human pathogen to model yeast (Joseph Heitman, June Kwon-Chung, John Perfect, Arturo Casadevall, Thomas R. Kozel, eds.). ASM Press, Washington, DC, 2011.

Morgann C. Reilly, Steven B. Levery, Sherry A. Castle, J. Stcey Klutts, and Tamara L. Doering. A novel xylsoylphosphotransferase activity discovered in Cryptococcus neoformans. J. Biol. Chem. 284:3618-3627, 2009. [PDF]

REVIEW ARTICLE: Tamara L. Doering. How sweet it is! Capsule formation and cell wall biogenesis in Cryptococcus neoformans. Annual Reviews of Microbiology, 63:223-247, 2009.[PDF]

Aki Yoneda and Tamara L. Doering. An unusual organelle in C. neoformans links luminal pH and capsule synthesis. Fungal Genetics and Biology, 46:682-687, 2009. [PDF]

REVIEW ARTICLE: Morgann C. Reilly and Tamara L. Doering. Biosynthesis of fungal and yeast glycans. In:  Microbial Glycobiology: Structures, Relevance, and Applications (Anthony Moran, Patrick Brennan, Otto Holst, and Mark von Itzstein, eds.), Elsevier Press, Inc., San Diego, CA,2009.

Christian Heiss, J. Stacey Klutts, Zhirui Wang, Tamara L. Doering, and Parastoo Azadi. The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid. Carbohydrate Research, 344:915-920, 2009. [PDF]

REVIEW ARTICLE: Richard D. Cummings and Tamara L. Doering. Chapter 21: Fungi, In: Essentials of Glycobiology, 2nd edition. (Ajit Varki, et al, editors). Cold Spring Harbor Press, Cold Spring Harbor, NY, 2008. [Text link]

Sherry A. Castle, Elizabeth Owuor, Stephanie H. Thompson, Michelle R. Garnsey, J. Stacey Klutts, Tamara L. Doering, and Steven B. Levery. Glycosphingolipidomic analysis of Cryptococcus neoformans xylose pathway knockout strains.  Beta-1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycolipids. Eukaryotic Cell, 7, 1611-5, 2008. [PDF]

J. Stacey Klutts and Tamara L. Doering. Cryptococcal xylosyltransferase 1 (Cxt1p) from Cryptocococus neoformans plays a direct role in the synthesis of capsule polysaccharides. J. Biol. Chem. 283, 14327-14334, 2008. [PDF]

Aki Yoneda and Tamara L. Doering. Regulation of Cryptococcus neoformans capsule size is mediated at the polymer level. Eukaryotic Cell, 7, 546-549, 2008. [PDF]

J. Stacey Klutts, Steven B. Levery, and Tamara L. Doering. A beta-1,2-xylosyltransferase from Cryptococcus neoformans defines a new family of glycosyltransferases. J. Biol. Chem. 282, 17890-17899, 2007. [PDF]

Tricia R. Cottrell, Cara L. Griffith, Hong Liu, Ashley A. Nenninger, andTamara L. Doering. The pathogenic fungus Cryptococcus neoformans expresses two functional GDP-mannose transporters with distinct expression patterns and roles in capsule synthesis. Eukaryotic Cell, 6, 776-785, 2007. [PDF] Cover image. [Cover]

Amy J. Reese, Aki Yoneda, Julia A. Breger, Anne Beauvais, Hong Liu, Cara L. Griffith, Indrani Bose, Myoung-Ju Kim, Colleen Skau, Sarah Yang, Julianne Sefko, Masako Osumi, Jean-Paul Latge, Eleftherios Mylonakis, and Tamara L. Doering. Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence. Molecular Microbiology, 63, 1385-1398, 2007. [PDF] Cover image. [Cover PDF]

Aki Yoneda and Tamara L. Doering. A eukaryotic capsular polysaccharide is synthesized intracellularly and secreted via exocytosis. Molecular Biology of the Cell, 17, 5131-5140, 2006. [PDF]

REVIEW ARTICLE: J. Stacey Klutts, Aki Yoneda, Morgann Reilly, Indrani Bose, and Tamara L. Doering. Glycosyltransferases and their products: Cryptococcal variations on fungal themes. FEMS Yeast Research, 6, 499-512, 2006. [PDF[

Stephen M. Beverley, Katherine L. Owens, Melissa Showalter, Cara L. Griffith, Tamara L. Doering, Victoria C. Jones, and Michael R. McNeil. Idenitfication of eukaryotic UDP-galactopyranose mutase in microbial and metazoal pathogens. Eukaryotic Cell, 4, 1147-1154, 2005. [PDF]

Brendan Loftus et al. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science, 307, 1321-1324, 2005. [PDF] [supplementary material]

Cara Griffith, J. Stacey Klutts, Lijuan Zhang, Steven B. Leverey, and Tamara L. Doering. UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus Cryptococcus neoformans. J. Biol. Chem. 279, 51669-51676, 2004. [PDF]

Aaron Tenney, Randall Brown, Charles Vasquez, Jennifer K. Lodge, Tamara L. Doering, and Michael R. Brent. Predicting genes in the genome sequence of Cryptococcus neoformans, a fungal pathogen with numerous extremely short introns. Genome Research, 14, 2330-2335, 2004.[PDF]

Isabelle Mouyna, Christine Henry, Tamara L. Doering, and Jean-Paul Latge. Gene silencing with RNA interference in the human pathogenic fungus Aspergillus fumigatus. FEMS Microbiol. 237, 317-324, 2004. [PDF]

Jeramia J. Ory, Cara L. Griffith, and Tamara L. Doering. Copper regulation of gene transcription in Cryptococcus neoformans. Yeast, 21, 919-926, 2004. [PDF]

Maor Bar-Peled, Cara L. Griffith, Jeramia J. Ory, and Tamara L. Doering. Biosynthesis of UDP-GlcA, a key metabolite for capsular polysaccharide synthesis in the pathogenic fungus Cryptococcus neoformans. Biochemical J., 381, 131-136, 2004. [PDF]

Amy J. Reese and Tamara L. Doering. Cell wall alpha-1,3-glucan is required to anchor the Cryptococcus neoformans capsule. Molecular Microbiology, 50, 1401-1409, 2003. [PDF]

Ulf Sommer, Hong Liu, and Tamara L. Doering. An alpha-1,3-mannosyl transferase of Cryptococcus neoformans. J. Biol. Chem., 278, 47724-47730, 2003. [PDF]

REVIEW ARTICLE: Tricia R. Cottrell and Tamara L. Doering. Silence of the strands: RNA interference in eukaryotic pathogens. Trends in Microbiology, 11, 37-43, 2003. [PDF]

REVIEW ARTICLE: Indrani Bose, Amy J. Reese, Jeramia J. Ory, Guilhem Janbon, and Tamara L. Doering. A yeast under cover: The capsule of Cryptococcus neoformans. Eukaryotic Cell, 2, 655-663, 2003. [PDF]

Maor Bar-Peled, Cara L. Griffith, and Tamara L. Doering. Functional cloning and characterization of a UDP-glucuronic acid decarboxylase: The pathogenic fungus Cryptococcus neoformans elucidates UDP-xylose synthesis. Proc. Natl. Acad. Sci. USA, 98, 12003-12008, 2001. [PDF]

Hong Liu, Tricia R. Cottrell, Lynda M. Pierini, William E. Goldman, and Tamara L. Doering. RNA interference in the pathogenic fungus Cryptococcus neoformans. Genetics, 160, 463-470, 2002.[PDF]

Lynda Pierini and Tamara L. Doering. Spatial and temporal sequence of capsule construction in Cryptococcus neoformans. Molecular Microbiology, 141, 105-115, 2001. [PDF]

REVIEW ARTICLE: Tamara L. Doering. How does Cryptococcus get its coat? Trends in Microbiology, 8, 545-551, 2000. [Response to a comment on this article Trends in Microbiology 9, p. 113 (2001).] [PDF]

Tamara L. Doering. A unique alpha-1,3 mannosyl transferase of the pathogenic fungus Cryptococcus neoformans. J. Bacteriol., 181, 5482-5488, 1999. [PDF]

Sarah P. Franzot and Tamara L. Doering. Specificity of GPI inositol acylation in Cryptococcus neoformans. Biochem. J., 340, 25-32, 1999. [PDF]

Lin-Chi Chen, David L. Goldman, Tamara L. Doering, Liise-anne Pirofski, and Arturo Casadevall. The antibody response to Cryptococcus neoformans proteins in rodents and humans. Infection & Immunity, 67, 2218-2224, 1999.

Tamara L. Doering, Joshua D. Nosanchuk, Wendy K. Roberts and Arturo Casadevall. Melanin interactions with protein: A potential cryptococcal defense against microbicidal proteins. Medical Mycology, 37, 175-182, 1999.


Non-crypto publications by Tamara L. Doering

Primary data papers

David A. Bernlohr, Tamara L. Doering, Thomas J. Kelly, Jr. and M. Daniel Lane. Tissue specific expression of p422 protein, a putative lipid carrier in mouse adipocytes. Biochem. Biophys. Res. Comm. 132, 850-855, 1985.

David W. Saffen, Kathleen A. Presper, Tamara L. Doering and Saul Roseman. Molecular cloning and structural analysis of the E. coli ptsH, ptsI, and crr genes. J. Biol. Chem. 262, 16241-16253, 1987.

James D. Bangs, Tamara L. Doering, Paul T. Englund and Gerald W. Hart. Biosynthesis of a variant surface glycoprotein of Trypanosoma brucei: Processing of the glycolipid membrane anchor and N-linked oligosaccharides. J. Biol. Chem. 263, 17697-17705, 1988.

Wayne J. Masterson, Tamara L. Doering, Gerald W. Hart and Paul T. Englund. A novel pathway for glycan assembly: Biosynthesis of the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Cell 56, 793-800, 1989.

Tamara L. Doering, Wayne J. Masterson, Paul T. Englund, and Gerald W. Hart. Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein: Origin of the non-acetylated glucosamine. J. Biol. Chem. 264, 11168-11173, 1989.

Jessica L. Krakow, Tamara L. Doering, Wayne J. Masterson, Gerald W. Hart and Paul T. Englund. A glycolipid from Trypanosoma brucei related to the variant surface glycoprotein membrane anchor. Mol. Biochem. Parasitol. 36, 263-270, 1989.

Mark F. Bean, James D. Bangs, Tamara L. Doering, Paul T. Englund, Gerald W. Hart, Catherine Fenselau, and Robert J. Cotter. Assessing heterogeneity of the high-mannose glycopeptide gp432 on the variant surface glycoprotein of trypanosomes: A comparison of plasma desorption mass spectrometry and radiolabeling techniques. Anal. Chem., 61, 2686-2688, 1989.

Wayne J. Masterson, Jayne Raper, Tamara L. Doering, Gerald W. Hart, and Paul T. Englund. Fatty acid remodeling: A novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors. Cell, 62, 73-80, 1990.

Tamara L. Doering, Jayne Raper, Laurence U. Buxbaum, Jeffrey I. Gordon, Steven P. Adams, Gerald W. Hart, and Paul T. Englund. An analog of myristic acid with selective toxicity for African trypanosomes. Science, 252, 1851-1854, 1991.

Tamara L. Doering, Melissa S. Pessin, Eleanor F. Hoff, Gerald W. Hart, Dan M. Raben, and Paul T. Englund. Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. J. Biol. Chem. 268, 9215-9222, 1993.

Tamara L. Doering, Melissa S. Pessin, Gerald W. Hart, Daniel M. Raben, and Paul T. Englund. The fatty acids in unremodeled trypanosome phosphatidylinositols. Biochem. J., 299, 741-746, 1994.

Tamara L. Doering, Tianbao Lu, Karl A. Werbovetz, George Gokel, Gerald W. Hart, Jeffrey I. Gordon, and Paul T. Englund. The toxicity of myristic acid analogs towards African trypanosomes. Proc. Natl. Acad. Sci. USA, 91, 9735-9739, 1994.

Tamara L. Doering and Randy Schekman. GPI-anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COP II vesicles. EMBO J., 15, 182-191, 1996.

Christine Sütterlin, Tamara L. Doering, Frauke Schimmöller, Stephan Schröder and Howard Riezman. Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. J. Cell Science, 111, 2703-2714, 1997.

Tamara L. Doering and Randy Schekman. GPI anchor attachment in a yeast in vitro system. Biochem. J., 328, 669-675, 1997.

Reviews and Methods

Paul T. Englund, Jessica L. Krakow, Dale Hereld, Tamara L. Doering, Wayne J. Masterson and Gerald W. Hart. Biosynthesis of the trypanosome variant surface glycoprotein: Attachment of the glycolipid membrane anchor. In: Molecular Basis of the Action of Drugs and Toxic Substances (N. Castognoli, T.P. Singer and C.C. Wang, eds.) Walter de Gruyter, New York, 1987.

Dale Hereld, Jessica L. Krakow, Tamara L. Doering, Wayne J. Masterson, Gerald W. Hart, and Paul T. Englund. The membrane-anchoring glycolipid of the trypanosome variant surface glycoprotein. In: Post-Translational Modification of Proteins by Lipids (U. Brodbeck and C. Bordier, eds.) Springer-Verlag, Berlin, 1987.

Paul T. Englund, Dale Hereld, Jessica L. Krakow, Tamara L. Doering, Wayne J. Masterson and Gerald W. Hart. The glycolipid anchor of the trypanosome variant surface glycoprotein: Its biosynthesis and cleavage. In: The Biology of Parasitism (P. Englund and A. Sher, eds.), Alan R. Liss, Inc., New York, 1988.

Tamara L. Doering, Wayne J. Masterson, Gerald W. Hart, and Paul T. Englund. Biosynthesis of glycosyl phosphatidylinositol membrane anchors. J. Biol. Chem., 265, 611-614, 1990.

Tamara L. Doering, Jayne Raper, Laurence U. Buxbaum, Gerald W. Hart, and Paul T. Englund. Biosynthesis of glycosyl phosphatidylinositol protein anchors. Methods: A Companion to Methods in Enzymology, 1, 288-296, 1990.

Kojo Mensa-Wilmot, Tamara L. b, Jayne Raper, Laurence U. Buxbaum, Gerald W. Hart, and Paul T. Englund. Glycosyl phosphatidylinositol membrane anchors in African trypanosomes. In: Molecular and Immunological Aspects of Parasitism (C.C. Wang, ed.), AAAS Press, Washington, D. C., 1991.

Tamara L. Doering. Glycosyl phosphatidylinositol protein anchors of African trypanosomes: Biosynthesis and therapeutic implications. Ph.D. dissertation, Johns Hopkins University, 1991.

Jayne Raper, Tamara L. Doering, Lawrence U. Buxbaum, and Paul T. Englund. Glycosyl phosphatidylinositols in Trypanosoma brucei. Experimental Parasitology 76, 216-220, 1993.

Tamara L. Doering, Paul T. Englund, and Gerald W. Hart. Detection of glycophospholipid protein anchors on proteins. In: Current Protocols in Molecular Biology, F. A. Ausubel et al, Eds., Unit 17, Analysis of Glycoconjugates, Guest Eds. A. Varki and J. Coligan, Greene Publishing and Wiley-Interscience, NY. 1993.

Tamara L. Doering. Glycosylphosphoinositol linkages of membrane glycoproteins. In: Cell Surface and Extracellular Glycoconjugates: Structure and Function (David D. Roberts and Robert P. Mecham, eds.), Academic Press, Inc., Orlando, Fla. 1993.

Randy Schekman, Charles Barlowe, Sebastian Bednarak, Joe Campbell, Tamara Doering, Rainer Duden, Meta Kuehn, Michael Rexach, Tom Yeung, and Lelio Orci. Coat Proteins and selective protein packaging into transport vesicles. Cold Spring Harbor Symposium on Quantitative Biology, 60, 11-21, 1995.